Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations.

Obes Res 2005 May;13(5):823-8

Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA.

We examined the association between obesity and 13 angiotensin-converting enzyme (ACE) gene polymorphisms, including the presence (I) or absence (D) of an Alu element in intron 16 (I/D polymorphism), and performed haplotype analysis using data collected from participants of a community survey of hypertension among blacks living in Ibadan, Nigeria; Spanish Town, Jamaica; and Chicago, IL. Transmission distortion of ACE gene polymorphisms and haplotypes from heterozygous parents to affected offspring was examined in each study population. To estimate haplotypes, polymorphisms were divided into three groups based on their position on the ACE gene. No ACE gene polymorphism was consistently overtransmitted from parents to obese offspring among the three populations. However, the haplotype ACE1-ACE5 TACAT, located in the promoter region, was significantly overtransmitted from parents to obese offspring in both the U.S. and Nigerian populations. No haplotype was significantly overtransmitted from parents to obese offspring among the Jamaicans. In conclusion, we noted the overtransmission of a particular ACE gene promoter region haplotype from parents to obese offspring in two separate black populations. These data suggest that ACE gene polymorphisms may influence the development of weight gain.

Download full-text PDF

Source
http://doi.wiley.com/10.1038/oby.2005.94
Publisher Site
http://dx.doi.org/10.1038/oby.2005.94DOI Listing
May 2005
3 Reads

Publication Analysis

Top Keywords

ace gene
24
parents obese
16
obese offspring
16
gene polymorphisms
16
overtransmitted parents
12
promoter region
8
black populations
8
populations haplotype
8
angiotensin-converting enzyme
8
gene
7
ace
6
offspring
5
parents
5
polymorphisms
5
polymorphisms divided
4
gene ace
4
haplotypes polymorphisms
4
position ace
4
divided three
4
gene polymorphism
4

References

(Supplied by CrossRef)
Prostacyclin as an indicator of preadipocyte transformation: studies in vivo by microdialysis and in vitro
Darimont et al.
Cancer Res. 1994
Impact of the renin-angiotensin system on lipid and carbohydrate metabolism
Strazzullo et al.
Curr Opin Nephrol Hypertens. 2004

Similar Publications