FGF-21 as a novel metabolic regulator.

J Clin Invest 2005 Jun 2;115(6):1627-35. Epub 2005 May 2.

Lilly Research Laboratories, Division of Eli Lilly and Co., Indianapolis, Indiana 46285, USA.

Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here we describe a potential novel therapeutic agent for this disease, FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes. FGF-21-transgenic mice were viable and resistant to diet-induced obesity. Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice. These effects persisted for at least 24 hours following the cessation of FGF-21 administration. Importantly, FGF-21 did not induce mitogenicity, hypoglycemia, or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

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http://www.jci.org/articles/view/23606
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http://dx.doi.org/10.1172/JCI23606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088017PMC
June 2005
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