The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver.

Authors:
Dr. Zbigniew K Binienda, DVM, PhD
Dr. Zbigniew K Binienda, DVM, PhD
FDA/NCTR
Research Scientist
Neurophysiology; Neurotoxicology
Little Rock, AR | United States

Neurosci Lett 2005 Jun 28;381(3):354-7. Epub 2005 Mar 28.

Division of Neurotoxicology, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.

The inhibitor of mitochondrial enzyme succinate dehydrogenase, 3-nitropropionic acid (3-NPA), induces cellular energy deficit followed by oxidative stress, secondary excitotoxicity and neuronal degeneration. The fast activation of Jun and Fos proteins and other proteins encoding inducible transcription factors (ITFs) occurs in most tissues upon exposure to a variety of stressors including exposure to mitochondrial inhibitors. However, the consequences of this activation can differ dramatically in different organs. For example, while activation of the same ITFs may lead to apoptosis and necrosis in neurons it may stimulate liver regeneration. Here, we report the alterations in mRNAs levels of c-Fos, JunB, and Krox20 proteins induced in the rat brain and liver by the acute exposure to 3-NPA at 30 mg/kg, s.c. While the increase of c-fos transcripts was observed in both the hippocampus and liver, the junb transcript increased in the hippocampus but decreased in the liver. No changes were observed in krox-20 mRNA in the hippocampus. Interestingly, there was a large variation in krox-20 mRNA levels in the liver among animals within the same experimental group. In conclusion, out of the three ITFs transcripts examined here junb may activate different pathways depending on the tissue as indicated by differential responses to mitochondrial inhibition in the hippocampus and liver.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2005.02.049DOI Listing
June 2005
18 Reads
1 Citation
2.060 Impact Factor

Publication Analysis

Top Keywords

hippocampus liver
12
succinate dehydrogenase
8
krox-20 mrna
8
liver
7
hippocampus
5
c-fos transcripts
4
activation differ
4
consequences activation
4
mitochondrial inhibitors
4
inhibitors consequences
4
liver animals
4
differ dramatically
4
example activation
4
activation itfs
4
variation krox-20
4
organs example
4
mrna levels
4
levels liver
4
dramatically organs
4
animals experimental
4

Similar Publications