Depress Anxiety 2005 ;21(2):78-89
Department of Psychiatry, Université Catholique de Louvain, Louvain, Belgium.
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J Int Neuropsychol Soc 2005 Sep;11(5):535-44
Department of Psychiatry, Université Catholique de Louvain, Bruxelles, Belgium.
Background: Divergences in cognitive disturbances in hypothyroidism reported in the literature are a result of a methodological bias.
Methods: By using a precise methodology, we examined attention and executive functions in hypothyroidism, verified the presence of anxiety and depressive symptoms in hypothyroidism, and examined the possible link between these symptoms and the cognitive disturbances (searching for attentional bias for words with a negative emotional valence). We administered a battery of cognitive tests to 23 participants who had undergone thyroidectomy for thyroid carcinoma: for the first time in an euthyroid state, then 3 weeks later (still in the euthyroid state) to assess the test/retest effect, and finally 4 weeks later in an hypothyroid state. Read More
Neuropsychobiology 2009 6;59(1):34-42. Epub 2009 Mar 6.
Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
Background: There is a relative scarcity of studies on major depressive disorder that use objective assessment methods to explore the psychomotor effects of antidepressants. Striatal dopaminergic disturbances are known to be involved in the pathogenesis of major depressive disorder that is associated with psychomotor retardation. Because of its additional dopaminergic mechanism, the psychomotor effects of the selective serotonin reuptake inhibitor sertraline merit further exploration. Read More
J Clin Exp Neuropsychol 2006 Jul;28(5):790-807
Department of Psychiatry, Université Catholique de Louvain, Belgium.
Little is known about the possible link between the cognitive disorders associated with hypothyroidism and those encountered in depression. This study examines attentional and executive functions as well as the intensity of anxiety and depressive symptoms in hypothyroidism and major depression and the possible link between these symptoms and cognitive disturbances. This study confirms the existence of psychomotor slowing associated with attentional and executive disturbance in major depression as well as in hypothyroidism. Read More
Encephale 2002 Mar-Apr;28(2):97-107
Service de Psychiatrie d'Adultes (Professeur Allilaire), Hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris cedex 13.
While several neuropsychological studies have demonstrated that cognitive deficits are seen across a broad range of cognitive domains, executive deficits associated with frontal lobe dysfunction may be prominent in depression. Executive function refers to cognitive processes that control and integrate other cognitive activities such as episodic memory. These executive functions involve a set of cognitive behaviors which include: dealing with novelty, selecting strategies, inhibiting incorrect responses, monitoring performance and using feedback to adjust future responding. Read More