An event-related functional magnetic resonance imaging study of voluntary and stimulus-driven orienting of attention.

Authors:
Richard A Abrams
Richard A Abrams
Washington University
United States
Serguei V Astafiev
Serguei V Astafiev
Washington University School of Medicine
Gordon L Shulman
Gordon L Shulman
Washington University School of Medicine
United States
Maurizio Corbetta
Maurizio Corbetta
Washington University School of Medicine
United States

J Neurosci 2005 May;25(18):4593-604

Department of Psychology, Washington University in St. Louis, St. Louis, Missouri 63130-4899, USA.

Attention can be voluntarily directed to a location or automatically summoned to a location by a salient stimulus. We compared the effects of voluntary and stimulus-driven shifts of spatial attention on the blood oxygenation level-dependent signal in humans, using a method that separated preparatory activity related to the initial shift of attention from the subsequent activity caused by target presentation. Voluntary shifts produced greater preparatory activity than stimulus-driven shifts in the frontal eye field (FEF) and intraparietal sulcus, core regions of the dorsal frontoparietal attention network, demonstrating their special role in the voluntary control of attention. Stimulus-driven attentional shifts to salient color singletons recruited occipitotemporal regions, sensitive to color information and part of the dorsal network, including the FEF, suggesting a partly overlapping circuit for endogenous and exogenous orienting. The right temporoparietal junction (TPJ), a core region of the ventral frontoparietal attention network, was strongly modulated by stimulus-driven attentional shifts to behaviorally relevant stimuli, such as targets at unattended locations. However, the TPJ did not respond to salient, task-irrelevant color singletons, indicating that behavioral relevance is critical for TPJ modulation during stimulus-driven orienting. Finally, both ventral and dorsal regions were modulated during reorienting but significantly only by reorienting after voluntary shifts, suggesting the importance of a mismatch between expectation and sensory input.

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0236-05.2005DOI Listing

Still can't find the full text of the article?

Sign up to send a request to the authors directly.
May 2005
11 Reads

Publication Analysis

Top Keywords

attention network
8
voluntary stimulus-driven
8
voluntary shifts
8
stimulus-driven orienting
8
attentional shifts
8
stimulus-driven shifts
8
preparatory activity
8
color singletons
8
frontoparietal attention
8
stimulus-driven attentional
8
attention
7
stimulus-driven
6
shifts
6
voluntary
5
color dorsal
4
dorsal network
4
network including
4
sensitive color
4
field fef
4
regions sensitive
4

Similar Publications

Gender disparities with the use of percutaneous left ventricular assist device in patients undergoing percutaneous coronary intervention complicated by cardiogenic shock: From pVAD Working Group.

Indian Heart J 2018 Jul 30;70 Suppl 1:S90-S95. Epub 2018 Apr 30.

Department of Cardiology, North Shore University Hospital, Northwell Health, Manhasset, NY, United States.

Background: Hemodynamic support with Impella (Abiomed Inc., Danvers, MA) devices is becoming a more prevalent treatment option for patients with cardiogenic shock (CS) undergoing percutaneous coronary intervention (PCI). There exists only limited published data regarding outcome differences between male and female patients. Read More

View Article
July 2018
23 Reads

miR-34a, miR-424 and miR-513 inhibit MMSET expression to repress endometrial cancer cell invasion and sphere formation.

Oncotarget 2018 May 1;9(33):23253-23263. Epub 2018 May 1.

Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan.

Although the oncogene MMSET (also known as NSD2 or WHSC1) has an essential role in malignancies, its impact on human endometrial cancer (EC) metastasis and the molecular mechanism of MMSET regulation are largely unknown. We report that MMSET was markedly upregulated in EC cell lines and EC tissues, and was significantly associated with poor survival in EC. MMSET overexpression greatly promoted EC cell invasion and sphere formation, whereas inhibition of MMSET reduced EC cell invasion and sphere formation. Read More

View Article
May 2018
14 Reads
6.36 Impact Factor

Urinary CD80 as a Replacement for Renal Biopsy for Diagnosis of Pediatric Minimal Change Disease.

Iran J Kidney Dis 2018 03;12(2):107-111

Departement of Pediatrics, Faculty of Medicine, Beni-Suef University, Egypt.

Introduction: Early diagnosis of minimal change disease (MCD) is challenging in nephrotic children. CD80 is a protein expressed on the surface of podocytes associated with nephrotic syndrome and it is implicated in the induction of proteinuria. This study aimed to investigate the use of urinary CD80 for the diagnosis of MCD. Read More

View Article
March 2018
5 Reads
0.98 Impact Factor

De-novo and acquired resistance to immune checkpoint targeting.

Lancet Oncol 2017 12;18(12):e731-e741

Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:

Use of immune checkpoint inhibitors targeting the programmed cell death protein-1/programmed cell death-ligand 1 and cytotoxic T lymphocyte-associated protein-4 axes has yielded impressive results in some clinical trials. However, only a subset of patients initially respond to these inhibitors, and increasing clinical evidence indicates that a substantial proportion of initial responders ultimately relapse with lethal, drug-resistant disease months or years later. Studies that have used massively parallel sequencing have shed light on the rich functional landscape of mutations that endow tumour cells with the ability to evade T-cell-mediated immunosurveillance. Read More

View Article
December 2017
16 Reads
12 PubMed Central Citations(source)
24.69 Impact Factor

Human T-lymphotropic virus type 1 infection and disease in Spain.

AIDS 2017 07;31(12):1653-1663

aPuerta de Hierro Research Institute, Majadahonda, Madrid bHospital Vall d'Hebrón, Barcelona cHospital de Conxo-CHUS, Santiago de Compostela dClinic University Hospital, Valladolid eBlood and Tissue Bank, Barcelona fRegional Transfusion Center, Madrid gCentro de Hemoterapia de Castilla-León, Valladolid hHospital Miguel Servet, Zaragoza iHospital Clínico Universitario Lozano Blesa, Zaragoza jUniversity Clinic kComplejo Hospitalario, Pamplona lCentro Sanitario Sandoval, Madrid mCristal-Piñor Hospital, Orense nGeneral Hospital, Alicante oHospital Virgen del Rocío, CIBERESP, Seville pRio Ortega Hospital, Valladolid qLa Paz University Hospital, Autonomous University, Madrid, Spain.

: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants). Read More

View Article
July 2017
36 Reads
5.55 Impact Factor