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Clin Transl Med 2021 Feb;11(2):e280

Department of Biomedicine, Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain.

CD19-directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B-cell malignancies, specially in B-cell acute lymphoblastic leukemia (B-ALL). However, CAR T-cell-treated patients eventually progress due to poor CAR T-cell persistence and/or disease relapse. The bone marrow (BM) is the primary location for acute leukemia. Read More

Cell Mol Bioeng 2021 Feb 4;14(1):65-74. Epub 2021 Feb 4.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 USA.

Introduction: E-selectin is a member of the selectin family of cell adhesion molecules expressed on the plasma membrane of inflamed endothelium and facilitates initial leukocyte tethering and subsequent cell rolling during the early stages of the inflammatory response binding to glycoproteins expressing sialyl Lewis and sialyl Lewis (sLe). Existing crystal structures of the extracellular lectin/EGF-like domain of E-selectin complexed with sLe have revealed that E-selectin can exist in two conformation states, a low affinity (bent) conformation, and a high affinity (extended) conformation. The differentiating characteristic of the two conformations is the interdomain angle between the lectin and the EGF-like domain. Read More

Cell Chem Biol 2021 Feb 7. Epub 2021 Feb 7.

Department of Chemical and Biological Engineering, State University of New York, 906 Furnas Hall, Buffalo, NY, USA; Department of Medicine, State University of New York, Buffalo, NY, USA. Electronic address:

There is a critical need to develop small-molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is effective only at millimolar concentrations. This article demonstrates that AcGalNTGc, a peracetylated C-2 sulfhydryl-substituted GalNAc, fulfills this unmet need. Read More

J Nanobiotechnology 2021 Feb 17;19(1):50. Epub 2021 Feb 17.

Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, Wales, UK.

Background: Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system. However, the adhesive properties of these mucins at the endometrial cell surface are difficult to resolve due to known discrepancies between in vivo models and the human reproductive system and a lack of sensitivity in current in vitro models. To overcome these limitations, an in vitro model of the human endometrial epithelial was interrogated with single molecule force spectroscopy (SMFS) to delineate the molecular configurations of mucin proteins that mediate the high affinity L-selectin binding required for human embryo implantation. Read More

Forensic Sci Int Genet 2020 Dec 25;52:102451. Epub 2020 Dec 25.

Canary Center at Stanford for Cancer Early Detection, Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, CA 94304, USA. Electronic address:

Rapid and efficient processing of sexual assault evidence will accelerate forensic investigation and decrease casework backlogs. The standardized protocols currently used in forensic laboratories require the continued innovation to handle the increasing number and complexity of samples being submitted to forensic labs. Here, we present a new technique leveraging the integration of a bio-inspired oligosaccharide (i. Read More