Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding.

Phytother Res 2004 Dec;18(12):1005-7

Department of Pharmacy, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 microM, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4',6'-trimethoxychalcone from K. rotunda were 45.6 and 57.4 microM, respectively. 1-Methoxy-2-methyl-5-(1',5'-dimethylhex-4'-enyl)-benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 microM. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors.

Download full-text PDF

Source
http://dx.doi.org/10.1002/ptr.1608DOI Listing
December 2004

Publication Analysis

Top Keywords

receptor binding
8
ic50 values
8
inhibitory effects
8
mutica exhibited
4
isolated mutica
4
56-dehydrokawain isolated
4
alpinetin 56-dehydrokawain
4
exhibited ic50
4
416 593
4
values 416
4
effects alpinetin
4
593 microm
4
compounds inhibitory
4
paf antagonistic
4
factor paf
4
platelet-activating factor
4
investigated platelet-activating
4
antagonistic activities
4
activities rabbit
4
ligand compounds
4

Similar Publications