Corcoran Lecture. Cardiovascular genomics and oxidative stress.

Hypertension 2005 Apr 7;45(4):636-42. Epub 2005 Feb 7.

BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Western Infirmary, University of Glasgow, Scotland, UK.

The majority of modifiable cardiovascular risk factors are complex, polygenic, or at least oligogenic traits, with genetic and environmental determinants playing important roles in disease risk and its phenotypic expression. The Human Genome Project and subsequent mouse and rat genome data have provided powerful tools to commence the dissection of genetic determinants of hypertension and other cardiovascular risk factors. Despite several new methodologies such as genome-wide scans, genome-wide gene expression profiling, and proteomic screens, it is fair to say that the progress of genetic studies designed as nonhypothesis driven has been relatively slow. On the other hand, several interesting candidate pathways have been identified, where investigators allowed for hypothesis-driven functional studies. One example of such pathway is vascular oxidative stress with its extensive network of genes and proteins, many with proven contributions to cardiovascular disease. Therefore, in parallel to genome-wide or proteome-wide studies, it will be constructive to pursue "pathwayomics" defined here as functional studies of a candidate pathway for disease pathogenesis.

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.HYP.0000154253.53134.09DOI Listing
April 2005
46 Reads

Publication Analysis

Top Keywords

risk factors
8
functional studies
8
oxidative stress
8
cardiovascular risk
8
studies designed
4
designed nonhypothesis
4
genetic studies
4
studies
4
fair progress
4
progress genetic
4
nonhypothesis driven
4
driven slow
4
candidate pathways
4
pathways identified
4
interesting candidate
4
tools commence
4
slow hand
4
hand interesting
4
screens fair
4
commence dissection
4

References

(Supplied by CrossRef)
Article in Nat Genet
Nat Genet 2003

Similar Publications