Defining smooth muscle cells and smooth muscle injury.

J Clin Invest 2005 Feb;115(2):221-4

Department of Pathology, University of Washington, Seattle, Washington 98195-7335, USA.

For 3 decades, terms such as synthetic phenotype and contractile phenotype have been used to imply the existence of a specific mechanism for smooth muscle cell (SMC) responses to injury. In this issue of the JCI, Hendrix et al. offer a far more precise approach to examining the mechanisms of SMC responses to injury, focused not on general changes in phenotype but on effects of injury on a single promoter element, the CArG [CC(A/T)6GG] box, in a single gene encoding smooth muscle (SM) alpha-actin. Since CArG box structures are present in some, but not all, SMC genes, these data suggest that we may be progressing toward establishing a systematic, molecular classification of both SMC subsets and the response of SMCs to different injuries.

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http://dx.doi.org/10.1172/JCI24272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546433PMC
February 2005
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Curr. Opin. Lipidol. 1994

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