A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

J Am Chem Soc 2005 Feb;127(5):1340-1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.

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Source
http://dx.doi.org/10.1021/ja044631vDOI Listing
February 2005

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