The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.

Authors:
Mark Rosenzweig
Mark Rosenzweig
Foundation Medicine
United States
Karen M Brennan
Karen M Brennan
United States
Timothy D Tayler
Timothy D Tayler
California Institute of Technology
Dr. Paul O Phelps, MD
Dr. Paul O Phelps, MD
NorthShore University HealthSystem
Attending Surgeon
Ophthalmology, Ophthalmic Plastic and Reconstructive Surgery, Ophthalmic Pathology
Chicago, IL | United States
Ardem Patapoutian
Ardem Patapoutian
Howard Hughes Medical Institute
United States
Paul A Garrity
Paul A Garrity
Brandeis University
Waltham | United States

Genes Dev 2005 Feb 28;19(4):419-24. Epub 2005 Jan 28.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Thermotaxis is important for animal survival, but the molecular identities of temperature sensors controlling this behavior have not been determined. We demonstrate dTRPA1, a heat-activated Transient Receptor Potential (TRP) family ion channel, is essential for thermotaxis in Drosophila. dTrpA1 knockdown eliminates avoidance of elevated temperatures along a thermal gradient. We observe dTRPA1 expression in cells without previously ascribed roles in thermosensation and implicate dTRPA1-expressing neurons in mediating thermotaxis. Our data suggest that thermotaxis relies upon neurons and molecules distinct from those required for high-temperature nociception. We propose dTRPA1 may control thermotaxis by sensing environmental temperature.

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Source
http://dx.doi.org/10.1101/gad.1278205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548941PMC
February 2005
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112 Citations
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