Replication timing of human chromosome 6.

Cell Cycle 2005 Jan 5;4(1):172-6. Epub 2005 Jan 5.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms. A replication timing map of the human genome has already been published at a 1Mb resolution. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity.

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Source
https://www.tandfonline.com/doi/full/10.4161/cc.4.1.1350
Publisher Site
http://dx.doi.org/10.4161/cc.4.1.1350DOI Listing
January 2005
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