Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages.

AIDS Res Hum Retroviruses 2004 Nov;20(11):1210-22

Department of Pathology, University of California San Diego, La Jolla, California 92093-0679, USA.

Macrophages represent one of the primary targets of HIV-1 infection. Changes in gene expression in primary human monocyte-derived macrophages following virus exposure were assessed using oligonucleotide arrays. Over a third of the 100 most modulated genes belonged to the interferon system. Upregulated interferon-stimulated genes included those essential for the innate immune response and also those involved in interferon and virus signal transduction from the cell surface. The promoter regions of a cluster of highly upregulated interferon-stimulated genes were analyzed for common regulatory elements. The nuclear factor in activated T cells (NFAT) and members of the interferon family of transcription factors appeared to be responsible for the upregulation of this set of interferon-stimulated genes following HIV-1 exposure.

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http://dx.doi.org/10.1089/aid.2004.20.1210DOI Listing
November 2004
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