Minimalist molecular model for nanopore selectivity.

Authors:
Dr. Mauricio Carrillo-Tripp, PhD
Dr. Mauricio Carrillo-Tripp, PhD
Biomolecular Diversity Laboratory, Cinvestav
Principal Investigator
Computational Biophysics
Monterrey, NL | Mexico

Phys Rev Lett 2004 Oct 14;93(16):168104. Epub 2004 Oct 14.

Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62210 Cuernavaca, Morelos, México.

Using a simple model it is shown that the cost of constraining a hydrated potassium ion inside a narrow nanopore is smaller than the cost of constraining the smaller hydrated sodium ion. The former allows for a greater distortion of its hydration shell and can therefore maintain a better coordination. We propose that in this way the larger ion can go through narrow pores more easily. This is relevant to the molecular basis of ion selective nanopores and since this mechanism does not depend on the molecular details of the pore, it could also operate in all sorts of nanotubes, from biological to synthetic.

Download full-text PDF

Source
http://dx.doi.org/10.1103/PhysRevLett.93.168104DOI Listing
October 2004
28 Reads
5 Citations
7.512 Impact Factor

Publication Analysis

Top Keywords

cost constraining
8
greater distortion
4
molecular basis
4
pore operate
4
distortion hydration
4
details pore
4
hydration shell
4
allows greater
4
operate sorts
4
hydrated sodium
4
sorts nanotubes
4
sodium ion
4
basis ion
4
ion allows
4
shell maintain
4
smaller hydrated
4
ion narrow
4
larger ion
4
mechanism depend
4
narrow pores
4

References

(Supplied by CrossRef)
Article in J. Physiol.
A. L. Hodgkin et al.
J. Physiol. 1952
Article in Biophys. J.
T. W. Allen et al.
Biophys. J. 1999
Article in Biochemistry
L. Guidoni et al.
Biochemistry 1999
Article in Biophys. J.
I. H. Shrivastava et al.
Biophys. J. 2000
Article in Biophys. J.
I. H. Shrivastava et al.
Biophys. J. 2000
Article in Biophys. J.
S. Bernèche et al.
Biophys. J. 2000

Similar Publications