Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni.

Virchows Arch 2004 Sep 30;445(3):285-91. Epub 2004 Jul 30.

Laboratory of Pathology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

Adults and children have differences in their susceptibility to schistosomiasis. Whether this age-dependent innate susceptibility influences parasite-caused granulomogenesis is difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. Hepatic and intestinal granuloma formation was observed in both pre-pubescent and adult monkeys. Two distinct stages of granulomas were discerned, the exudative and the productive stage. In the intestine, more granulomas were generated in the colon than in the ileum. In contrast to the adult animals, the juvenile rhesus monkeys had higher numbers of colonic granulomas, these higher numbers being predominantly of the more advanced productive stage. Juvenile animals had a statistically non-significant increased worm burden. These results suggest that juvenile rhesus monkeys have a significantly more intense and advanced colonic response towards entrapped S. mansoni eggs after primary schistosome infections and, thereby, are more susceptible to parasite infection.

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September 2004
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References

(Supplied by CrossRef)

Bogers et al.
Neurogastroenterol Motil 2000

Butterworth et al.
Parasitol Today 1994

Byram et al.
Am J Trop Med Hyg 1978

Cheever et al.
Am J Trop Med Hyg 1968

Cheever et al.
Am J Trop Med Hyg 1971

Cheever et al.
Bull World Health Organ 1972

Fallon et al.
Clin Diagn Lab Immunol 1998

Fallon et al.
J Infect Dis 2003

Fulford et al.
Parasitol Today 1998

Geboes et al.
Virchows Arch 1990

Ghandour et al.
Ann Trop Med Parasitol 1999

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