Genetic approaches to unraveling G protein-coupled receptor biology.

Curr Opin Drug Discov Devel 2004 Sep;7(5):658-64

University of Cambridge, Department of Oncology, Hutchison-MRC Research Centre, Addenbrookes, Cambridge CB2 2XZ, UK.

Genetic approaches to validating G protein-coupled receptors (GPCRs) have proven to be a powerful research tool, especially knockout studies in rodents. To date, data related to in vivo function have been published on approximately half of the human rhodopsin-like family-1 GPCRs, which can be attributed to the use of mouse knockouts. It is likely that many currently unknown yet important therapeutic mechanisms will be uncovered through knockout screens in mice. One such recent discovery is the elucidation of the in vivo function of the GPCR GPR54 through mouse genetics, and its subsequent validation in human populations. Although previously unsuspected, GPR54 has been found to be a master-regulator of the hypothalamic-pituitary-gonadal axis.

Download full-text PDF

Source
September 2004
3 Reads

Publication Analysis

Top Keywords

genetic approaches
8
vivo function
8
unknown therapeutic
4
currently unknown
4
therapeutic mechanisms
4
will uncovered
4
uncovered knockout
4
knockouts currently
4
mechanisms will
4
attributed mouse
4
half human
4
published half
4
function published
4
human rhodopsin-like
4
rhodopsin-like family-1
4
knockout screens
4
family-1 gpcrs
4
mouse knockouts
4
mice discovery
4
populations unsuspected
4

Similar Publications