Cancer Res 1998 Sep;58(18):4052-4
Department of Colorectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (<1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2. Read More