Evaluation of telomerase activity in nasal polyps.

Am J Rhinol 2004 Jul-Aug;18(4):197-201

Faculty of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

Background: The objective of this study was to assess if nasal polyps express telomerase activity and whether a difference could be found between the polyp and the surrounding mucosa of the middle meatus and between different portions of the polyp itself

Methods: Nine patients affected by nasal polyposis were included in this study; four of these patients had recurring polyposis. Telomerase activity was measured by telomeric repeat amplification protocol assay. In six patients, the telomeric repeat amplification protocol assay was performed on the polyp and on the mucosa from the ipsilateral middle meatus. In a polyp, we were able to investigate telomerase activity of its different portions, corresponding to pedicle and fundus.

Results: Telomerase activity observed in nasal polyps was higher than that observed in samples from the ipsilateral middle meatus mucosa. High or intermediate telomerase activity was found to be related to predominant recurring polyposis.

Conclusions: Therefore, it could be postulated that telomerase activity could be related with the tendency of polyps to recur.

Download full-text PDF

December 2004

Publication Analysis

Top Keywords

telomerase activity
nasal polyps
middle meatus
amplification protocol
repeat amplification
ipsilateral middle
telomeric repeat
protocol assay
meatus mucosa
study patients
patients recurring
recurring polyposis
samples ipsilateral
polyposis telomerase
meatus polyp
included study
high intermediate
patients nasal

Similar Publications

Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis.

Cancer Res 1998 Sep;58(18):4052-4

Department of Colorectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.

To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (<1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2. Read More

View Article and Full-Text PDF
September 1998

[Nitric oxide synthase activity in nasal mucosa].

Acta Otorrinolaringol Esp 1998 Oct;49(7):503-7

Departamento de ORL, Hospital General Universitario Valle de Hebrón, Barcelona.

Nitric oxide (NO) plays an important regulatory role in airway function and seems to be implicated in the pathophysiology of several airway diseases. We studied the presence of NO synthase activity in human nasal mucosa and nasal polyp tissues obtained from patients undergoing septoplasty or polypectomy, respectively. NO synthase activity was quantified in tissue homogenates using citrulline release assay and was located in tissue sections using NADPH-diaphorase histochemistry. Read More

View Article and Full-Text PDF
October 1998

Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients.

Laryngoscope 2006 Mar;116(3):417-22

Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan.

Objective/hypothesis: Nasal polyposis (NP) is a chronic inflammatory disease of the upper respiratory tract. The pathophysiology is unknown but has been shown to be multifactorial. Free radical-mediated damage has been implicated in the pathogenesis of NP. Read More

View Article and Full-Text PDF
March 2006

Airway inflammation in nasal polyposis: immunopathological aspects of relation to asthma.

Clin Exp Allergy 2005 Mar;35(3):319-26

Department of Allergic Diseases, School of Medicine, Ankara University, Ankara 06530, Turkey.

Background: Nasal polyposis (NP) is a chronic inflammatory disorder of the upper respiratory tract, which is often coexist with asthma. However, the pathogenesis of especially in patients with NP is still a matter of debate.

Objective: To better understand the immunopathologic mechanism involved in this relationship, we investigated the inflammatory cell profiles in bronchial and nasal tissues of patients with NP alone and with concomitant asthma. Read More

View Article and Full-Text PDF
March 2005