[The effects of DNA damage induced by acetaldehyde].

Huan Jing Ke Xue 2004 May;25(3):102-5

Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.

The effects of DNA damage induced by the typical environmental pollutant acetaldehyde were studied with single cell gel electrophoresis (SCGE) and high performance liquid chromatography with electrochemical detection (HPLC-EC). The results showed that acetaldehyde not only could cause DNA strand breakage but also DNA-DNA, DNA-protein crosslinks of lymphocytes of human peripheral blood. The reaction of acetaldehyde with DNA in vitro was weak, but the oxidative ability was enhanced and the reaction could produce a number of 8-OHdG adducts mediated by the Fe2+. The animal experiment shows that acetaldehyde can cause the oxidative DNA damage of rat lung tissues, which suggests that acetaldehyde have the potential genotoxicity and its chemical mechanism is relative to the crosslinks and oxidation with DNA.

Download full-text PDF

Source
May 2004
2 Reads

Publication Analysis

Top Keywords

dna damage
12
effects dna
8
damage induced
8
acetaldehyde dna
8
dna
6
acetaldehyde
5
dna-protein crosslinks
4
dna-dna dna-protein
4
crosslinks lymphocytes
4
oxidative dna
4
acetaldehyde oxidative
4
lymphocytes human
4
damage rat
4
dna strand
4
detection hplc-ec
4
lung tissues
4
8-ohdg adducts
4
hplc-ec acetaldehyde
4
human peripheral
4
strand breakage
4

Similar Publications