Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.

Circulation 2004 Aug 23;110(9):1121-7. Epub 2004 Aug 23.

Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria.

Background: Induction of postnatal vasculogenesis, the mobilization of bone marrow-derived endothelial progenitor cells and incorporation of these cells into sites of blood vessel formation, is a well-known feature of angiogenic cytokines such as vascular endothelial growth factor. We hypothesized that the angiogenic neuropeptide secretoneurin induces this kind of neovascularization.

Methods And Results: Secretoneurin induced mobilization of endothelial progenitor cells to sites of vasculogenesis in vivo in the cornea neovascularization assay. Progenitor cells were incorporated into vascular structures or were located adjacent to them. Systemic injection of secretoneurin led to increase of circulating stem cells and endothelial progenitor cells. In vitro secretoneurin induced migration, exerted antiapoptotic effects, and increased the number of these cells. Furthermore, secretoneurin stimulated the mitogen-activated protein kinase system, as shown by phosphorylation of extracellular signal-regulated kinase, and activated the protein kinase B/Akt pathway. Activation of mitogen-activated protein kinase was necessary for increase of cell number and migration, whereas Akt seemed to play a role in migration of endothelial progenitor cells.

Conclusions: These data show that the angiogenic neuropeptide secretoneurin stimulates postnatal vasculogenesis by mobilization, migration, and incorporation of endothelial progenitor cells.

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.CIR.0000139884.81390.56DOI Listing
August 2004
12 Reads

Publication Analysis

Top Keywords

progenitor cells
20
endothelial progenitor
20
postnatal vasculogenesis
12
protein kinase
12
angiogenic neuropeptide
12
cells sites
8
neuropeptide secretoneurin
8
mitogen-activated protein
8
secretoneurin induced
8
vasculogenesis mobilization
8
cells
8
secretoneurin
7
progenitor
6
endothelial
6
structures located
4
kinase increase
4
secretoneurin led
4
led increase
4
activation mitogen-activated
4
injection secretoneurin
4

References

(Supplied by CrossRef)

Blood 1998

Similar Publications