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Actas Dermosifiliogr 2021 Feb 17. Epub 2021 Feb 17.

Instituto Universitario Fernández-Vega (IUFV), Universidad de Oviedo, Oviedo, España; Departamento de Biología Funcional, Universidad de Oviedo, Oviedo, España. Electronic address:

Background And Objective: Superficial mycoses are some of the most common diseases worldwide. The usual culprits - yeasts belonging to the genera Malassezia and Candida - are commensal species in the skin that can cause opportunistic infections. We aimed to determine whether these yeasts use glycosaminoglycans (GAGs) as adhesion receptors to mediate binding to epithelial cells. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2021 ;98(1):71-78

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The article presents the data of the latest domestic and foreign original studies, the results of a number of meta-analyses, conclusions of randomized clinical trials (RCTs), and other scientific studies that prove the effectiveness and necessity of mandatory inclusion in the treatment of chronic pain syndrome of the stage of non-invasive non-pharmacological therapy. One of the promising areas of pharmacotherapy for degenerative-dystrophic joint lesions is the use of chondroprotectors (CP), in particular chondroitin sulfate (CS). According to new Clinical Recommendations of Ministry Health (MH) of the Russian Federation (RF) «Chronic pain in patients of elderly and senile age» (2020), according to which the purpose of CS is recommended for patients older than 60 years with joint pain and contraindications to non-steroidal anti-inflammatory drugs (NSAIDs) or senile asthenia for the purpose of pain relief and the prevention of exacerbations of pain. Read More

Biomed Res Int 2021 2;2021:6949864. Epub 2021 Feb 2.

Department of Acupuncture & Massage, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310014, China.

Objective: This work analyzes the role of versican (VCAN) on bladder cancer (BLCA). Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer. However, the expression of VCAN on human bladder cancer (BLCA) has been rarely reported. Read More

Cell Mol Neurobiol 2021 Feb 17. Epub 2021 Feb 17.

Department of Orthopaedics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No 6, Beijing West Road, Huai'an, 223300, Jiangsu, People's Republic of China.

Studies have found that molecular targets that regulate tissue development are also involved in regulating tissue regeneration. Erythropoietin-producing hepatocyte A4 (EphA4) not only plays a guiding role in neurite outgrowth during the development of the central nervous system (CNS) but also induces injured axon retraction and inhibits axon regeneration after spinal cord injury (SCI). EphA4 targets several ephrin ligands (including ephrin-A and ephrin-B) and is involved in cortical cell migration, axon guidance, synapse formation and astrocyte function. Read More

J Mater Chem B 2021 Feb 17. Epub 2021 Feb 17.

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China.

A hierarchical multichannel polydopamine (HMPDA) nanoparticle with ample chondroitin sulfate (CS) is fabricated via modification of the silane coupling agent (APTES), followed by grafting CS on the unique bicontinuous open channels of HMPDA through amidation reaction. The obtained nanoparticles with both mesopores and macropores, abbreviated as HMPDA-A-CS15, possess a total pore volume of 0.3398 cm3 g-1, and a large surface area up to 69. Read More