J Neurosci 2004 Apr;24(16):4043-51
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5K8, Canada.
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Anticancer Agents Med Chem 2018 09 10. Epub 2018 Sep 10.
Divisions of Biochemistry & Chemistry, City University of New York School of Medicine, 160 Convent Avenue, New York, NY10031. United States.
Backgrounds: Neoplasm metastasis is a multi-step and multi-level pathological feature causing 90% of cancer mortality due to a shortage of effective drugs and clinical therapeutics. To change this scenario, new drug targets and developments are required.
Method: Aberrant tumor sialylation as a putative drug target candidate has been evolving over the past half century. Read More
BMC Complement Altern Med 2018 May 16;18(1):159. Epub 2018 May 16.
Laboratory of Microbiology and Antimicrobial substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Background: Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases.
Methods: The plant extracts were prepared by maceration in ethanol. Read More
J Biol Dyn 2017 Dec;11(1):378-435
a Modelling Health and Environmental Linkages Research Group (MHELRG), Department of Mathematics and Applied Mathematics , University of Venda , Thohoyandou, South Africa.
Modelling of infectious disease systems has entered a new era in which disease modellers are increasingly turning to multiscale modelling to extend traditional modelling frameworks into new application areas and to achieve higher levels of detail and accuracy in characterizing infectious disease systems. In this paper we present a categorization framework for categorizing multiscale models of infectious disease systems. The categorization framework consists of five integration frameworks and five criteria. Read More
Electrophoresis 2017 03 30;38(6):846-854. Epub 2017 Jan 30.
Office of Chief Medical Examiner, Department of Forensic Biology, New York, NY, USA.
This study assesses the performance of Illumina's MiSeq FGx System for forensic genomics by systematically analyzing single source samples, evaluating concordance, sensitivity and repeatability, as well as describing the quality of the reported outcomes. DNA from 16 individuals (9 males/7 females) in nine separate runs showed consistent STR profiles at DNA input ≥400 pg, and two full profiles were obtained with 50 pg DNA input. However, this study revealed that the outcome of a single sample does not merely depend on its DNA input but is also influenced by the total amount of DNA loaded onto the flow cell from all samples. Read More
Cell Cycle 2008 Sep 15;7(18):2846-55. Epub 2008 Sep 15.
Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
We previously found that the pro-apoptotic DNA damaging agent, cisplatin, mediated the proteasome-dependent degradation of Delta Np63 alpha associated with its increased phosphorylated status. Since Delta Np63 alpha usually plays an opposite role to p53 and TAp63 in human cancers, we tested the notion that phosphorylation events induced by DNA damage would affect the protein degradation of Delta Np63 alpha in HNSCC cells upon cisplatin exposure. We found that Delta Np63 alpha is phosphorylated in the time-dependent fashion at the following positions: S385, T397 and S466, which were surrounded by recognition motifs for ATM, CDK2 and p70s6K kinases, respectively. Read More