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Ann Nucl Med 2021 Mar 4. Epub 2021 Mar 4.

Institute for Radiation Sciences, Osaka University, Osaka, Japan.

Objective: F-labeled prostate-specific membrane antigen (PSMA) ligand, [F]PSMA-1007, has the benefit of a higher synthetic yield and minimal excretion in the urine. High detection efficacy was reported in biochemical recurrence (BCR) of prostate cancer after radical prostatectomy. Thus, we evaluated the preliminary diagnostic utility of [F]PSMA-1007 PET in patients with prostate cancer, focusing on the BCR which is not detected on conventional imaging. Read More

Clin Nucl Med 2021 Mar 4. Epub 2021 Mar 4.

From the Department of Radiation Oncology, Adana Dr Turgut Noyan Research and Treatment Center, Baskent University Faculty of Medicine, Adana Department of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara Division of Radiation Oncology, Memorial Sisli Hospital Department of Radiation Oncology, Acıbadem MAA University Maslak Hospital Department of Radiation Oncology, Istanbul Bilim University, Istanbul Division of Radiation Oncology, Iskenderun Gelisim Hospital, Hatay Department of Radiation Oncology, Acıbadem MAA University Atakent Hospital Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.

Purpose: To evaluate the outcomes of metastasis-directed treatment (MDT) using stereotactic body radiotherapy (SBRT) for bone-only oligometastasis (OM) detected with gallium prostate-specific membrane antigen (68Ga-PSMA) PET/CT in castration-sensitive prostate cancer (PC) patients.

Methods: In this multi-institutional study, clinical data of 74 PC patients with 153 bone lesions who were undergoing MDT were retrospectively evaluated. Twenty-seven patients (36. Read More

J Pediatr Hematol Oncol 2021 Mar 3. Epub 2021 Mar 3.

Departments of Pediatric Oncology Radiology, Shaukat Khanum Cancer Hospital, Lahore, Pakistan.

Osteosarcoma is the most common primary malignant bone tumor in children. In addition to pulmonary metastasis, computed tomography frequently detects indeterminate pulmonary nodules (IPN). We conducted this study to determine the clinical significance of IPN in terms of progression to pulmonary metastasis and its impact on survival. Read More

Front Bioeng Biotechnol 2021 15;9:629928. Epub 2021 Feb 15.

Zhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Haining, China.

Osteosarcoma is a malignant tumor that often occurs in adolescents and children. Zoledronic acid, a new-generation bisphosphonate, has been widely used as an antitumor drug to inhibit bone metastasis. However, the rapid renal elimination results in low effective concentrations. Read More

J Extracell Vesicles 2021 Feb 18;10(4):e12068. Epub 2021 Feb 18.

Department of Orthopedics Southwest Hospital Third Military Medical University Chongqing 400038 China.

Extracellular vesicles (EVs) play critical roles in regulating bone metastatic microenvironment through mediating intercellular crosstalks. However, little is known about the contribution of EVs derived from cancer cells to the vicious cycle of bone metastasis. Here, we report a direct regulatory mode between tumour cells and osteoclasts in metastatic niche of prostate cancer via vesicular miRNAs transfer. Read More