Nutrition and schizophrenia: beyond omega-3 fatty acids.

Authors:
Malcolm Peet

Prostaglandins Leukot Essent Fatty Acids 2004 Apr;70(4):417-22

Swallownest Court Hospital, Aughton Road, Sheffield S26 4th, UK.

There are now five placebo-controlled trials of EPA in the treatment in schizophrenia, and four of these have given positive or partly positive findings. A cross-national ecological analysis of international variations in outcome of schizophrenia in relation to national dietary practices, showed that high consumption of sugar and of saturated fat is associated with a worse long-term outcome of schizophrenia. It is known that a high sugar, high fat diet leads to reduced brain expression of brain-derived neurotrophic factor (BDNF) which is responsible for maintaining the outgrowth of dendrites. Low brain BDNF levels also lead to insulin resistance which occurs in schizophrenia and is associated with diseases of the metabolic syndrome. It appears that the same dietary factors which are associated with the metabolic syndrome, including high saturated fat, high glycaemic load, and low omega-3 PUFA, may also be detrimental to the symptoms of schizophrenia, possibly through a common mechanism involving BDNF.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plefa.2003.12.019DOI Listing
April 2004

Publication Analysis

Top Keywords

outcome schizophrenia
8
metabolic syndrome
8
saturated fat
8
schizophrenia
5
high
5
long-term outcome
4
worse long-term
4
schizophrenia high
4
sugar high
4
associated diseases
4
high fat
4
associated worse
4
high sugar
4
diseases metabolic
4
outgrowth dendrites
4
high consumption
4
syndrome appears
4
consumption sugar
4
sugar saturated
4
fat associated
4

Similar Publications