Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets.

Leuk Lymphoma 2003 Dec;44(12):2099-102

CLIP--Childhood Leukaemia Investigation, Prague, Czech Republic.

A unique case of ALL in three monozygotic triplets diagnosed at the age of 24, 27 and 37 months is described. Archived bone marrow smears were available for molecular analysis of immunoglobulin heavy chain (IGH) and IGK genes and T-cell receptor (TCR)-delta and gamma gene rearrangements. A shared IGH rearrangement was found in triplets "A" and "B", and an identical rearrangement of TCR-delta in triplets "B" and "C". These data suggest a common, monoclonal initiation of ALL in one of these three triplets, followed by dissemination of clonal progeny to the other twins via vascular anastomoses within the single, monochorionic placenta that they shared in utero. Differences in IGH rearrangements in diagnostic samples also indicates divergent subclonal evolution of the original "pre-leukaemic" clone.

Download full-text PDF

Source
http://dx.doi.org/10.1080/1042819031000123393DOI Listing
December 2003
7 Reads

Publication Analysis

Top Keywords

triplets
5
rearrangement tcr-delta
4
tcr-delta triplets
4
identical rearrangement
4
"b" identical
4
triplets "b"
4
"b" "c"
4
monoclonal initiation
4
initiation three
4
common monoclonal
4
data common
4
"c" data
4
"a" "b"
4
triplets "a"
4
receptor tcr-delta
4
t-cell receptor
4
genes t-cell
4
igk genes
4
tcr-delta gamma
4
gamma gene
4

References

(Supplied by CrossRef)

Wiemels J.L. et al.
Blood 1999

Fasching K. et al.
Blood 2000

Yagi T. et al.
Blood 2000

Similar Publications