Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study.

Am J Kidney Dis 2004 Feb;43(2):244-53

Clinical Trial Service Unit, University of Oxford, Oxford, UK.

Background: Studies in the general population suggest that low-grade inflammation, endothelial dysfunction, and platelet activation are associated with an increased risk of cardiovascular events.

Methods: Markers of inflammation, endothelial dysfunction, and platelet activation were measured in 334 patients with chronic kidney disease (serum creatinine >1.47 mg/dL [>130 micromol/L] at screening) and compared with 2 age- and sex-matched control groups, 1 comprising 92 patients with coronary artery disease and the other comprising 96 apparently healthy individuals with no history of cardiovascular or kidney disease.

Results: There was evidence of low-grade inflammation in the chronic renal impairment group compared with healthy controls, with higher concentrations of C-reactive protein (3.70 versus 2.18 mg/L, P < 0.01) and fibrinogen (3.48 versus 2.67 g/L, P < 0.001) and lower serum albumin concentration (41.8 versus 44.0 g/dL [418 versus 440 g/L], P < 0.001). More severe renal impairment was associated with a trend towards higher fibrinogen and lower albumin concentrations (both P < 0.001), although there was no association with higher C-reactive protein level. As compared to healthy controls, plasma von Willebrand factor (142 versus 108 IU/dL, P < 0.001) and soluble P-selectin concentrations (57.0 versus 43.3 ng/mL, P < 0.001) were also higher in the chronic renal impairment group. More severe renal impairment was associated with a trend towards higher levels of von Willebrand factor (P < 0.001) and of soluble P selectin (P < 0.05).

Conclusion: This cross-sectional analysis demonstrates that chronic kidney disease is associated with low-grade inflammation, endothelial dysfunction, and platelet activation, even among patients with moderate renal impairment.

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ajkd.2003.10.037DOI Listing
February 2004
11 Reads

Publication Analysis

Top Keywords

renal impairment
24
platelet activation
16
endothelial dysfunction
16
dysfunction platelet
16
inflammation endothelial
16
kidney disease
12
chronic renal
12
low-grade inflammation
12
chronic kidney
12
von willebrand
8
willebrand factor
8
severe renal
8
c-reactive protein
8
associated trend
8
impairment associated
8
versus 440
8
trend higher
8
compared healthy
8
healthy controls
8
impairment group
8

Altmetric Statistics

Similar Publications