Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation.

Org Lett 2004 Feb;6(3):385-8

Department of Chemistry, University of Massachusetts, Amherst 01003, USA.

[structure: see text] A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and pi-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

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http://dx.doi.org/10.1021/ol036279gDOI Listing
February 2004
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