Cross-couplings of alkyl electrophiles under "ligandless" conditions: Negishi reactions of organozirconium reagents.

J Am Chem Soc 2004 Jan;126(1):82-3

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

This report establishes that simple, "ligandless" palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.

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Source
http://dx.doi.org/10.1021/ja0393729DOI Listing
January 2004

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