Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation.

J Pediatr Hematol Oncol 2004 Jan;26(1):5-8

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.

Download full-text PDF

Source
http://dx.doi.org/10.1097/00043426-200401000-00003DOI Listing
January 2004
1 Read

Publication Analysis

Top Keywords

malignant infantile
12
infantile osteopetrosis
12
marrow transplantation
8
bone marrow
8
tracp bone-specific
4
phosphatase tracp
4
alkaline phosphatase
4
phosphatase bap
4
acid phosphatase
4
bone-specific alkaline
4
tartrate-resistant acid
4
compared biochemical
4
response compared
4
biochemical response
4
response bone
4
markers tartrate-resistant
4
metabolic markers
4
bap treatment
4
successful decrease
4
assessment malignant
4

Similar Publications