Haplotype structure and evidence for positive selection at the human IL13 locus.

Mol Biol Evol 2004 Jan 29;21(1):29-35. Epub 2003 Aug 29.

Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, China.

Interleukin-13 (IL13) is believed to play an important role in the pathogenesis of atopy and allergic asthma. To better understand genetic variation at the IL13 locus, we resequenced a 5.1-kb genomic region spanning the entire locus and identified 26 single-nucleotide polymorphisms (SNPs) in 74 individuals from three major populations-Chinese, Caucasian, and African. Our survey suggests exceptionally high and significant geographic structure at the IL13 locus between African and outside Africa populations. This unusual pattern suggests that positive selection that acts in some local populations may have played a role on the IL13 locus. In support of this suggestion, we found a significant excess of high frequency-derived SNPs in the Chinese population and Caucasian population, respectively, as expected after a recent episode of positive selection. Further, the unusual haplotype structure indicates that different scenarios of the action of positive selection on the IL13 locus in different populations may exist. In the Caucasian population, the skewed haplotype distribution dominated by one common haplotype supports the hypothesis of simple directional selection. Whereas, in the Chinese population, the two-round hitchhiking hypothesis may explain the skewed haplotype structure with three dominant ones. These findings may provide insight into the likely relative roles of selection and population history in establishing present-day variation at the IL13 locus, and, motivate further studies of this locus as an important candidate in common diseases association studies.

Download full-text PDF

Source
http://dx.doi.org/10.1093/molbev/msg231DOI Listing
January 2004
5 Reads

Publication Analysis

Top Keywords

il13 locus
24
positive selection
16
haplotype structure
12
variation il13
8
chinese population
8
caucasian population
8
locus
8
skewed haplotype
8
il13
7
selection
6
population
5
haplotype
5
episode positive
4
expected episode
4
selection unusual
4
populations exist
4
population caucasian
4
population expected
4
unusual haplotype
4
scenarios action
4

Similar Publications