Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours.

Anticancer Res 2003 May-Jun;23(3C):3057-9

Department of Orthopaedics, University of Vienna, Vienna General Hospital, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

Objective: To determine serum levels of TNF-beta and soluble TNF-R in patients with primary highly malignant bone tumours.

Patients And Methods: Sera of 27 patients with highly malignant osteosarcoma and Ewing sarcoma were taken at the time of diagnosis and analysed by ELISA.

Results: Both TNF-beta and sTNF-R levels were lower in sera from osteosarcoma patients as compared to those from Ewing sarcoma. In patients with high-grade osteosarcoma, but not Ewing sarcoma, high levels of TNF-beta correlated with bad response to neoadjuvant chemotherapy.

Conclusion: In patients with high-grade osteosarcoma TNF-beta levels seem to be of predictive value and both TNF-beta and sTNF-R seem to be of diagnostic value for differentiation between high-grade osteosarcoma and Ewing sarcoma.

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September 2003
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