Liver desaturase activities and FA composition in monkeys. Effect of a low-protein diet.

Lipids 2003 May;38(5):525-9

Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, (1900) La Plata, Buenos Aires, Argentina.

The aim of the present study was to measure delta9-, delta6-, and delta5-desaturase activities in liver microsomes, as well as phospholipid FA composition of liver and erythrocytes in monkeys fed a control or low-protein diet during the postweaning period. Ten Saimiri sciureus boliviensis (Cebidae) of both sexes were employed; at 12 mon of age they were separated into two groups fed ad libitum on a control or a low-protein diet for 24 mon. Saimiri sciureus had active delta9, delta6, and delta5 liver desaturase enzymes, and these activities were influenced by the diet. A low-protein diet produced a significant reduction in delta5-desaturation capacity, an increase in delta9-desaturase activity, and no change in delta6-desaturase activity (P < 0.05). These changes, evoked by protein deprivation, were reflected in the liver phospholipid FA composition. Increases in the proportion of saturated FA and in monounsaturated oleic acid (18:1n-9) and a decrease in the proportion of PUFA of the n-6 and n-3 series were produced in the animals fed a low-protein diet (P < 0.0001).

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http://dx.doi.org/10.1007/s11745-003-1094-9DOI Listing
May 2003

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