Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20.

Blood 2003 Nov 10;102(9):3206-9. Epub 2003 Jul 10.

Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA.

In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified.

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-05-1419DOI Listing
November 2003
21 Reads

Publication Analysis

Top Keywords

multipotential progenitors
12
progenitors il-20
12
mice increased
8
il-20
6
multipotential
5
progenitors
5
il-20 erythroid
4
erythroid granulocyte-macrophage
4
progenitor cells
4
formation cd34+
4
demonstrating il-20
4
enhanced colony
4
colony formation
4
cells demonstrating
4
granulocyte-macrophage megakaryocyte
4
cd34+ multipotential
4
il-20 transgenic
4
cell cycling
4
normal mice
4
cycling multipotential
4

Altmetric Statistics

Similar Publications