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J Natl Compr Canc Netw 2021 Mar 2;19(3):240-246. Epub 2021 Mar 2.

1Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute.

Historically, adolescent and young adult (AYA) patients with cancer, diagnosed for the first time at age 15 through 39 years, have often been identified as a "lost tribe" without a medical "home"; neither pediatric nor adult oncology services were able to provide age-appropriate care to this specific group. Internationally, AYA care programs are being established to bridge the gap between the age-defined healthcare worlds and to address the specific needs of AYAs with cancer. However, AYA care programs mostly focus on improving cure rates and addressing survivorship issues, and direct less attention to the unique needs of those living with an uncertain and/or poor cancer prognosis. Read More

J Fluency Disord 2021 Feb 27;70:105841. Epub 2021 Feb 27.

University of South Florida, Department of Communication Sciences & Disorders, 4202 East Fowler Avenue, PCD1017, Tampa, FL, 33620, United States. Electronic address:

Purpose: Based on previous evidence that cognitive control of lexical selection in object (noun) naming operates differently in adults who stutter (AWS) versus typically-fluent adults (TFA), the aim was to investigate cognitive control of lexical selection in action (verb) naming in AWS.

Method: 12 AWS and 12 TFA named line drawings depicting actions using verbs. Half of the pictures had high-agreement action names and the other half low-agreement action names. Read More

Int J Surg Case Rep 2021 Feb 22;80:105685. Epub 2021 Feb 22.

Division of Interventional Radiology, Department of Medical Imaging, Western University, 800 Commissioners Rd E, London, ON, N6A 5W9, Canada.

Introduction: Gastrocutaneous fistula complicating a post-operative or post-pancreatitis pancreatic fistula is uncommon, but has a high mortality rate and typically occurs 6-9 weeks after initial drainage. Conventional methods of treatment may be limited by the size of the fistula tract and visibility.

Presentation Of Case: A 57-year-old man presented with a pancreatic duct leak, ten days after undergoing a distal pancreatectomy for renal cell carcinoma metastasis. Read More

Curr Opin Struct Biol 2021 Mar 2;69:19-34. Epub 2021 Mar 2.

Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Kamenice 5/C13, 625 00 Brno, Czech Republic; International Centre for Clinical Research, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic. Electronic address:

Enzymes are in high demand for very diverse biotechnological applications. However, natural biocatalysts often need to be engineered for fine-tuning their properties towards the end applications, such as the activity, selectivity, stability to temperature or co-solvents, and solubility. Computational methods are increasingly used in this task, providing predictions that narrow down the space of possible mutations significantly and can enormously reduce the experimental burden. Read More

Pharmacol Res 2021 Mar 2:105524. Epub 2021 Mar 2.

Dept. of Medicine, Div. of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands; Dept. of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China. Electronic address:

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition, by increasing hepatic low density lipoprotein (LDL) receptor (LDLR) levels, has emerged as a strategy to reduce atherosclerosis by lowering circulating very low density lipoprotein (VLDL)-cholesterol. We hypothesized that the therapeutic effectiveness of PCSK9 inhibition can be increased by accelerating the generation of VLDL remnants, which typically have a high affinity for the LDLR. Therefore, we aimed to investigate whether accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL and reduce atherosclerosis on top of PCSK9 inhibition. Read More