A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype.

Psychophysiology 2003 Mar;40(2):277-84

Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA.

Smooth pursuit eye movement (SPEM) abnormalities in schizophrenia, although well described, are poorly understood. SPEMs are initiated by motion of an object image on the retina. During initiation, the eyes accelerate until they approximate target velocity and a state of minimal retinal motion is achieved. Pursuit is maintained through predictive eye movements based on extraretinal signals and corrections based on deviations from the fovea. Here, initiation and predictive pursuit responses were used to estimate the contributions of retinal and extraretinal signals to pursuit maintenance in schizophrenia patients' relatives. Relatives exhibited normal initiation, but had lower predictive pursuit gain compared with controls. Relatives had normal gain during pursuit maintenance, presumably by greater reliance on retinal error. This was confirmed by group differences in regression coefficients for retinal and extraretinal measures, and suggests that schizophrenia SPEM deficits involve reduced ability to maintain or integrate extraretinal signals, and that retinal error may be used to compensate.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698991PMC
http://dx.doi.org/10.1111/1469-8986.00029DOI Listing
March 2003
4 Reads

Publication Analysis

Top Keywords

extraretinal signals
12
retinal extraretinal
8
pursuit maintenance
8
retinal error
8
eye movement
8
predictive pursuit
8
pursuit eye
8
smooth pursuit
8
pursuit
7
retinal
5
corrections based
4
signals corrections
4
regression coefficients
4
based deviations
4
initiation predictive
4
pursuit responses
4
fovea initiation
4
deviations fovea
4
differences regression
4
eye movements
4

References

(Supplied by CrossRef)

Andreasen N. C. et al.
Archives of General Psychiatry 1986

Avila M. et al.
Journal of Abnormal Psychology 2002

Barnes G. R. et al.
Journal of Physiology 1991

Barnes G. R. et al.
Journal of Physiology 1992

Barnes G. R. et al.
Journal of Neurophysiology 2000

Barton J. J. et al.
Annals of Neurology 1996

Becker W. et al.
Experimental Brain Research 1985

Braun D. I. et al.
Experimental Brain Research 1996

Similar Publications