Myofibroblastoma of the larynx: a study of two cases.

Head Neck 2003 Jul;25(7):606-11

Department of Otolaryngology, The University of Texas Medical School, Houston, Texas, USA.

Background: We describe, for the first time, the occurrence of two pure examples of spindle cell neoplasm with fibrous and smooth muscle differentiation in the larynx.

Materials And Method: Tissue sections from both tumors stained with hematoxylin and eosin were reviewed. Immunophenotypic analysis using keratin, S-100 protein, SMA, and h-Caldesmon markers was performed.

Results: Tumors were seen as raised submucosal nodules in the glottic region of two elderly male patients. Histopathologically, the lesions were unencapsulated and composed of spindle cells that manifested variable cellular anaplasia and expressed SMA and were negative for keratin, S-100, and h-Caldesmon.

Conclusions: We document histologically low-grade malignant myofibroblastic tumors of the larynx. Complete excision is advised.

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http://dx.doi.org/10.1002/hed.10272DOI Listing
July 2003
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References

(Supplied by CrossRef)

Batsakis et al.
Surg Gynecol Obstet 1970

Johnson et al.
2000

Patel et al.
Am J Otolaryngol 2001

Schurch et al.
Am J Surg Pathol 1998

Eyden et al.
Histol Histopathol 2001

Mentzel et al.
Curr Diagn Pathol 2001

Watanabe et al.
Am J Surg Pathol 2002

Smith et al.
Pediatr Pathol Lab Med 1995

Troccanier-Pelte et al.
Am J Pathol 1987

Biselli et al.
Pathol Res Pract 1999

Wargotz et al.
Am J Surg Pathol 1987

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