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Fetal Diagn Ther 2021 Apr 14:1-11. Epub 2021 Apr 14.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose: We examined select pulmonary effects and donor cell kinetics after transamniotic stem cell therapy (TRASCET) in a model of congenital diaphragmatic hernia (CDH).

Methods: Pregnant dams (n = 58) received nitrofen on gestational day 9.5 (E9) to induce fetal CDH. Read More

Cureus 2021 Mar 10;13(3):e13813. Epub 2021 Mar 10.

General Surgery, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Penetrating chest injuries can lead to diaphragmatic injuries, which are often missed easily on initial assessments, especially in patients with polytrauma. We are usually more focused and biased towards other evident, immediately life-threatening injuries. The fact that clinical and radiological findings are subtle, especially on chest X-rays, which is sometimes the only investigation performed, highlights the importance of using higher imaging modalities in stable patients and that a clinician should be suspicious of this entity with the corresponding history. Read More

Am J Case Rep 2021 Apr 14;22:e930441. Epub 2021 Apr 14.

Department of Surgery, Neuchâtel Hospital Network (RHNe) - Pourtalès, Neuchâtel, Switzerland.

BACKGROUND Pericardio-peritoneal windows are surgically created to treat symptomatic pericardial effusion, usually of oncological origin, to alleviate cardiac tamponade-like symptoms. Common complications include infection, failure to drain the fluid correctly, and arrythmias. There are few published cases of intra-abdominal complications due to these interventions. Read More

Neonatology 2021 Apr 13:1-8. Epub 2021 Apr 13.

John P. and Katherine G. McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.

Introduction: Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic hernia (CDH). We aimed to evaluate the association between early CDH-associated PH (CDH-PH) and inpatient outcomes.

Methods: The CDH Study Group registry was queried for infants born 2015-2019 with echocardiograms before 48h of life. Read More

Pediatr Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, Izumi, Japan.

Congenital diaphragmatic hernia (CDH) is a birth defect of the diaphragm in which abdominal organs herniate through the defect into the thoracic cavity. The main pathophysiology is respiratory distress and persistent pulmonary hypertension because of pulmonary hypoplasia caused by compression of the elevated organs. Recent progress in prenatal diagnosis and postnatal care has led to an increase in the survival rate of patients with CDH. Read More