Inhibitors of lysine biosynthesis as antibacterial agents.

Mini Rev Med Chem 2003 Mar;3(2):115-27

School of Chemistry, The University of Sydney, NSW 2006, Australia.

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

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http://dx.doi.org/10.2174/1389557033405359DOI Listing
March 2003
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