Search Our Scientific Publications & Authors

Angew Chem Int Ed Engl 2021 Apr 13. Epub 2021 Apr 13.

Tsinghua University, Department of Chemistry, CHINA.

Collective synthesis of skeletally diverse Stemona alkaloids has been achieved, featuring tailored dyotropic rearrangements of b -lactones as key elements. Specifically, three typical 5/7/5 tricyclic skeletons associated with stemoamide, tuberostemospiroline and parvistemonine were first accessed through chemoselective alkyl-, hydrogen-, and aryl-migration dyotropic rearrangements of b -lactones, respectively. With rational manipulations of substrate structures and reaction conditions, these dyotropic rearrangements proceeded with excellent efficiency, good chemoselectivity and high stereospecificity. Read More

J Sep Sci 2021 Apr 8. Epub 2021 Apr 8.

Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.

A valid and reliable method based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry using electrospray ionization was established to identify chemical constituents in the ethanol extract of pigeon pea leaves. A total of 58 compounds were detected both in positive and negative modes. Among them, 42 compounds including 16 flavones, 1 flavonol, 5 flavanones, 9 isoflavones, 1 coumarin, 1 lactone, 6 stilbenes, 2 chalcones and 1 other compound were unambiguously identified or tentatively assigned in view of the retention time, the molecular formula as well as the fragmentation patterns. Read More

Oxid Med Cell Longev 2021 16;2021:6692628. Epub 2021 Mar 16.

Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.

This work is aimed at investigating the expression levels of inducible nitric oxide synthase (iNOS) in cervical cancer and identifying a potential iNOS inhibitor. The data mining studies performed advocated iNOS to be a promising biomarker for cancer prognosis, as it is highly overexpressed in several malignant cancers. The elevated iNOS was found to be associated with poor survival and increased tumor aggressiveness in cervical cancer. Read More

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.

-Butyrolactone, a five-membered lactone moiety, is one of the privileged structures of diverse natural products and biologically active small molecules. Because of their broad spectrum of biological and pharmacological activities, synthetic methods for -butyrolactones have received significant attention from synthetic and medicinal chemists for decades. Recently, new developments and improvements in traditional methods have been reported by considering synthetic efficiency, feasibility, and green chemistry. Read More

Prog Chem Org Nat Prod 2021 ;115:59-114

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Maryland, The Johns Hopkins University School of Medicine, Baltimore, The Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD, 21231, USA.

Thapsigargin, the first representative of the hexaoxygenated guaianolides, was isolated 40 years ago in order to understand the skin-irritant principles of the resin of the umbelliferous plant Thapsia garganica. The pronounced cytotoxicity of thapsigargin is caused by highly selective inhibition of the intracellular sarco-endoplasmic Ca-ATPase (SERCA) situated on the membrane of the endo- or sarcoplasmic reticulum. Thapsigargin is selective to the SERCA pump and to a minor extent the secretory pathway Ca/Mn ATPase (SPCA) pump. Read More