Angew Chem Int Ed Engl 2002 Dec;41(23):4498-500
Department of Chemistry, University of Bremen, Germany.
Sci Adv 2021 Apr 2;7(14). Epub 2021 Apr 2.
Department of Earth and Environmental Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Carbon is an essential element for life, but its behavior during Earth's accretion is not well understood. Carbonaceous grains in meteoritic and cometary materials suggest that irreversible sublimation, and not condensation, governs carbon acquisition by terrestrial worlds. Through astronomical observations and modeling, we show that the sublimation front of carbon carriers in the solar nebula, or the soot line, moved inward quickly so that carbon-rich ingredients would be available for accretion at 1 astronomical unit after the first million years. Read More
Nat Commun 2021 03 3;12(1):1407. Epub 2021 Mar 3.
Princess Máxima Center for Pediatric Oncology, 3584CS, Utrecht, the Netherlands.
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. Here, we study the origin of MRT by combining phylogenetic analyses and single-cell mRNA studies in patient-derived organoids. Read More
Orthop Surg 2021 Feb 5;13(1):28-34. Epub 2021 Jan 5.
Department of Bone and Joint Surgery and Sports Medicine of Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Objective: To investigate the outcomes of humeral head replacement in the treatment of patients with comminuted proximal humeral fracture.Methods: Between February 2013 and September 2016, 56 patients underwent humeral head replacement in our hospital. Of them, 18 cases were diagnosed as comminuted proximal humeral fracture before the operation. Read More
Clin Orthop Relat Res 2021 Apr;479(4):651-663
E. Hasvik, Department of Physical Medicine and Rehabilitation, Østfold Hospital Trust, Norway.
Background: The frequency with which sensory disturbances occur in patients with radicular leg pain and disc herniation is not well known, and the efficacy of tests to identify such changes are not firmly established. The presence of sensory disturbances is a key sign of nerve root involvement and may contribute to the diagnosis of a lumbar disc herniation, identify patients for referral to spinal imaging and surgery, and improve disease classification.Questions/purposes: In this study, we sought: (1) to determine the frequency with which abnormal sensory findings occur in patients with lumbar disc herniation-related radicular pain, using a standard neurological sensory examination; (2) to determine what particular standard sensory test or combination of tests is most effective in establishing sensory dysfunction; and (3) to determine whether a more detailed in-depth sensory examination results in more patients being identified as having abnormal sensory findings. Read More
Acc Chem Res 2021 01 31;54(2):403-415. Epub 2020 Dec 31.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Drug-induced acute liver injury (DIALI) is increasingly recognized as a significant cause of acute liver injury (ALI), which is characterized by a rapid loss of hepatocyte function in patients without pre-existing liver diseases. Evaluation of corresponding biomarkers, including alanine transaminase and aspartate amino transferase, is available as a diagnostic tool for hepatotoxicity. However, these blood tests have certain limitations: (1) they are generally not available for early estimation; (2) it is difficult to visualize and identify hepatotoxicity unambiguously in real-time; and (3) the biomarkers are not unique and are usually influenced by a variety of diseases, leading to potential false results. Read More