Chem Biol Interact 2003 Jan;142(3):285-96
Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.
Food Chem Toxicol 2002 Aug;40(8):1077-83
Insitute of Cancer Research, University of Vienna, Borschkegasse 8A, 1090 Vienna, Austria.
The aim of this study was to investigate the chemoprotective effects of Brussels sprouts juice towards benzo[a]pyrene (B(a)P)-induced DNA damage in the single-cell gel electrophoresis (SCGE)/Hep G2 test system. This assay combines the advantages of the SCGE assay with that of the use of human-derived cells possessing inducible phase I and phase II enzymes. Co-treatment of Hep G2 cells with small amounts of Brussels sprouts juice (0. Read More
Teratog Carcinog Mutagen 2003 ;Suppl 1:273-82
Insitute of Cancer Research, University of Vienna, Austria.
The aim of this study was to investigate the chemoprotective effects of mustard sprouts on benzo(a)pyrene [B(a)P]-induced DNA damage in the single cell gel electrophoresis (SCGE)/Hep G2 assay. This model combines the advantages of the SCGE assay with that of human-derived cells that possess inducible phase I and phase II enzymes. Treatment of the cells with small amounts of mustard juice (0. Read More
Phytochemistry 2003 May;63(2):199-207
Hochschule Wädenswil, University of Applied Sciences, Pharmaceutical Biotechnology, Box 335, Gruental, CH-8820 Wädenswil, Switzerland.
The genotoxic and antigenotoxic activities of catechin, hamamelitannin and two proanthocyanidin fractions prepared from the bark of Hamamelis virginiana L. were investigated in a human derived, metabolically competent hepatoma cell line (Hep G2) using single cell gel electrophoresis (SCGE) for the detection of DNA-damage. DNA-migration was calculated as Olive tail moment (OTM). Read More
Carcinogenesis 2000 Sep;21(9):1711-9
University of Minnesota Cancer Center, Box 806 Mayo, Minneapolis, MN 55455, USA.
Benzyl isothiocyanate (BITC) inhibits lung tumorigenesis induced in A/J mice by benzo[a]pyrene (B[a]P). In contrast, phenethyl isothiocyanate (PEITC) does not. We tested the hypothesis that BITC inhibits B[a]P tumorigenicity in mouse lung by inhibiting DNA adduct formation, and compared the effects of BITC and PEITC. Read More