J Bacteriol 2002 Dec;184(24):6760-7
Mycobacterium Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.
J Mol Biol 2021 Feb 26:166901. Epub 2021 Feb 26.
Department of Biology, University of Konstanz, 78457 Konstanz, Germany. Electronic address:
Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. To date, the role of this interaction in the stress response of muscle remainspoorly understood. Here, we characterise the molecular structure of the CARP-receptor site in titin (UN2A) and its binding of CARP. Read More
Front Plant Sci 2021 10;12:584042. Epub 2021 Feb 10.
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, China.
Cytokinins (CKs) can modulate plant immunity to various pathogens, but how CKs are involved in plant defense responses to the necrotrophic pathogen is still unknown. Here, we found that infection induced transcriptional changes in multiple genes involved in the biosynthesis, degradation, and signaling of CKs, as well as their contents, in pathogen-infected leaves. Among the CKs, the gene expression of () was remarkably induced in the local infected leaves and the distant leaves of the same plant without pathogen inoculation. Read More
Front Microbiol 2021 12;12:637213. Epub 2021 Feb 12.
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Extracytoplasmic function (ECF) sigma factors underpin the ability of bacteria to adapt to changing environmental conditions, a process that is particularly relevant in human pathogens that inhabit niches where human immune cells contribute to high levels of extracellular stress. Here, we have characterized the previously unstudied RpoE2 ECF sigma factor from the human respiratory pathogen (Hi) and its role in hypochlorite-induced stress. Exposure of to oxidative stress (HOCl, HO) increased gene expression, and the activity of RpoE2 was controlled by a cytoplasmic 67-aa anti-sigma factor, HrsE. Read More
Microb Cell Fact 2021 Feb 27;20(1):53. Epub 2021 Feb 27.
Department of Endocrinology, Fuzhou Children's Hospital of Fujian Medical University, NO. 145, 817 Middle Road, Fuzhou, 350005, China.
Background: The term "metabolically healthy obese (MHO)" denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective: This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Read More
J Surg Res 2021 Feb 24;263:63-70. Epub 2021 Feb 24.
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Background: Molecular hydrogen (H) has been used in clinical cases. However, there are few studies of H therapy to treat sepsis, and anti-inflammatory mechanisms of H are mostly unknown. We aimed to confirm effects of H therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Read More