Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia.

Ann Neurol 2002 Sep;52(3):378-81

Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.

We report a 79-year-old woman with possible Alzheimer's disease and confluent periventricular white matter hyperintensities on magnetic resonance imaging in whom postmortem analysis unexpectedly demonstrated no periventricular demyelination or cerebral arteriosclerosis. However, astrocytes in the periventricular white matter exhibited clasmatodendrosis, defined as cytoplasmic swelling and vacuolation of astroglia, with beading of their dendrites. This finding represents a previously unrecognized correlate of periventricular white matter hyperintensities. Ann Neurol 2002;52:378-381

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http://doi.wiley.com/10.1002/ana.10310
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September 2002
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References

(Supplied by CrossRef)

Hachinski et al.
Arch Neurol 1987

Merino et al.
Arch Neurol 2000

Roman et al.
JAMA 1987

Munoz et al.
Arch Neurol 1993

Wiszniewska et al.
Arch Neurol 2000

Pantoni et al.
Stroke 1997

Penfield et al.
1928

Cavanagh et al.
Neuropathol Appl Neurobiol 1993

Tomimoto et al.
Acta Neuropathol (Berl) 1997

Akiguchi et al.
Stroke 1997

Rafalowska et al.
Neuropatol Pol 1992

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