Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury.

Eur J Pharmacol 2002 Aug;450(1):49-53

Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden.

We have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury.

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http://dx.doi.org/10.1016/s0014-2999(02)02052-6DOI Listing
August 2002
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