Amyotroph Lateral Scler Other Motor Neuron Disord 2002 Mar;3(1):43-6
Department of Neurology and ALS Clinic, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Objective: To evaluate the effect of creatine supplementation on the respiratory function of patients with advanced amyotrophic lateral sclerosis (ALS).
Methods: Five grams creatine daily were administered orally to 14 patients with definite advanced ALS. For comparison we used a group of 13 patients with a similar respiratory function. All patients performed pulmonary function testing including forced vital capacity (FVC), forced expiratory volume (FEV(1)), peak expiratory flow rate (PEF) and maximum voluntary ventilation (MVV) -- expressed as percent of the predicted value -- at baseline and each month thereafter.
Results: There was no significant difference in any measured variable between the treatment group and the control group at 1, 2, 3 and 4 months follow-up. Thereafter the high patient drop-out rate did not allow statistical evaluation.
Conclusion: The present study did not show any clinically significant, long-term effect of creatine on the function of respiratory muscles in ALS patients with respiratory distress.