Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis.

Clin Infect Dis 2002 Jul 6;35(1):96-101. Epub 2002 Jun 6.

Department of Internal Medicine, University of Oulu, Oulu, FIN-90014 Oulu, Finland.

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

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https://academic.oup.com/cid/article-lookup/doi/10.1086/3408
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http://dx.doi.org/10.1086/340859DOI Listing
July 2002
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