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Eur J Endocrinol 2021 Apr 1. Epub 2021 Apr 1.

H Ahlström, Department of surgical sciences, Uppsala University, Uppsala, 751 05, Sweden.

Objective: To obtain direct quantifications of glucose turnover, volumes and fat content of several tissues in the development of type 2 diabetes (T2D) using a novel integrated approach for whole-body imaging.

Design And Methods: Hyperinsulinemic-euglycemic clamps and simultaneous whole-body integrated [18F]FDG-PET/MRI with automated analyses were performed in control (n=12), prediabetes (n=16) and T2D (n=13) subjects matched for age, sex and BMI.

Results: Whole-body glucose uptake (Rd) was reduced by approximately 25% in T2D vs control subjects, and partitioning to brain was increased from 3. Read More

Diabetes Obes Metab 2021 Apr 14. Epub 2021 Apr 14.

Division of Diabetes, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas.

Aim: To identify predictors of response to glucose lowering therapy in patients with new onset diabetes and very high HbA1c (>10%).

Research Design And Methods: The study included EDICT participants with initial HbA1c >10% (N = 104). All subjects received a 75-g OGTT before initiation of therapy, and then were randomized to receive: (i) initial Triple Therapy with metformin, pioglitazone, and exenatide versus (ii) stepwise Conventional Therapy with metformin followed by glipizide and then glargine insulin to reduce A1c < 6. Read More

Breast Cancer Res Treat 2021 Apr 14. Epub 2021 Apr 14.

Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

Purpose: To compare efficacy and safety of capecitabine and lapatinib with or without IMC-A12 (cituxumumab) in patients with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab.

Patients And Methods: Following an initial safety run-in cohort, patients were randomized 1:2 to Arm A (capecitabine and lapatinib) or to Arm B (capecitabine, lapatinib, and cituxumumab). Given the frequency of non-hematologic grade ≥ 3 adverse events in those receiving the three-drug combination in the safety cohort, lapatinib and capecitabine doses were reduced in Arm B only. Read More

Wiad Lek 2021 ;74(1):77-82

KHARKIV MEDICAL ACADEMY OF POSTGRADUATE EDUCATION, KHARKIV, UKRAINE.

Objective: The aim: To study the relationship between zonulin level and PNFI (pediatric non-alcoholic fatty liver disease fibrosis index) in obese adolescents.

Patients And Methods: Material and methods: A total of fifty-nine obese subjects aged 12-17 years and thirteen healthy subjects were included in the study. Clinical, biochemical parameters, including serum zonulin, were examined and abdominal ultrasound examination was performed. Read More

Am J Physiol Regul Integr Comp Physiol 2021 Apr 14. Epub 2021 Apr 14.

Dalton Cardiovascular Research Center, Nutrition and Exercise Physiology, University of Missouri, United States.

Herein we report in a sample of healthy young men (n=14) and women (n=12) that hyperinsulinemia induces time-dependent decreases in total peripheral resistance and its contribution to the maintenance of blood pressure. In the same participants, we observe profound vasodilatory effects of insulin in the lower limb despite concomitant activation of the sympathetic nervous system. We hypothesized this prominent peripheral vasodilation is possibly due to an ability of the leg vasculature to escape sympathetic vasoconstriction during systemic insulin stimulation. Read More