Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

Cell 2002 Apr;109(1):47-60

Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

Wnt/Wingless signaling controls many fundamental processes during animal development. Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors. Here we report the identification of two segment polarity genes in Drosophila, legless (lgs), and pygopus (pygo), and we show that their products are required for Wnt signal transduction at the level of nuclear beta-catenin. Lgs encodes the homolog of human BCL9, and we provide genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin. Our results suggest that the recruitment of Pygo permits beta-catenin to transcriptionally activate Wnt target genes and raise the possibility that a deregulation of these events may play a causal role in the development of B cell malignancies.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0092-8674(02)00679-7DOI Listing
April 2002

Publication Analysis

Top Keywords

wnt/wingless signaling
8
encodes homolog
4
homolog human
4
lgs encodes
4
beta-catenin lgs
4
nuclear beta-catenin
4
human bcl9
4
bcl9 provide
4
evidence proteins
4
molecular evidence
4
genetic molecular
4
provide genetic
4
level nuclear
4
signal transduction
4
drosophila legless
4
legless lgs
4
genes drosophila
4
polarity genes
4
segment polarity
4
lgs pygopus
4

Similar Publications