Analysis of the complete genome of subgroup A' hepatitis B virus isolates from South Africa.

J Gen Virol 2002 Apr;83(Pt 4):835-839

MRC/CANSA/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa1.

A phylogenetic analysis is presented of six complete and seven pre-S1/S2/S gene sequences of hepatitis B virus (HBV) isolates from South Africa. Five of the full-length sequences and all of the pre-S2/S sequences have been previously reported. Four of the six complete genomes and three of the five incomplete sequences clustered with subgroup A', a unique segment of genotype A of HBV previously identified in 60% of South African isolates using analysis of the pre-S2/S region alone. This separation was also evident when the polymerase open reading frame was analysed, but not on analysis of either the X or pre-core/core genes. Amino acids were identified in the pre-S1 and polymerase regions specific to subgroup A'. In common with genotype D, 10 of 11 genotype A South African isolates had an 11 amino acid deletion in the amino end of the pre-S1 region. This deletion is also found in hepadnaviruses from non-human primates.

Download full-text PDF

Source
http://dx.doi.org/10.1099/0022-1317-83-4-835DOI Listing
April 2002
4 Reads

Publication Analysis

Top Keywords

south african
8
hepatitis virus
8
south africa
8
isolates south
8
african isolates
8
region separation
4
analysis
4
pre-s2/s region
4
identified 60%
4
analysis pre-s2/s
4
60% south
4
isolates analysis
4
genotype hbv
4
sequences clustered
4
polymerase regions
4
incomplete sequences
4
three incomplete
4
clustered subgroup
4
subgroup unique
4
isolates amino
4

References

(Supplied by CrossRef)
Variant of hepatitis B virus isolated in Zimbabwe
Chirara et al.
Journal of Medical Virology 1994
Identification of hepatitis B virus indigenous to chimpanzees
Hu et al.
Proceedings of the National Academy of Sciences, USA 2000
Constrained evolution with respect to gene overlap of hepatitis B virus
Mizokami et al.
Journal of Molecular Evolution 1997

Similar Publications