Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

The intrastromal corneal ring in clinical refractive surgery: reference to results in rabbit eyes.

Authors:
C Hartmann P W Rieck C Holzkämper Y Pouliquen G Renard

Graefes Arch Clin Exp Ophthalmol 2000 Jun;238(6):465-71

Department of Ophthalmology, Charité Medical Faculty , Humboldt University Berlin, Germany.

Background: The intrastromal corneal ring (ISR) is a refractive device recently introduced for clinical application that is implanted in the mid-peripheral corneal stroma in order to correct myopia without invasion of the central optical zone. First clinical results of intracorneal ring segment implantation were published recently. These results reveal striking similarities to our own experimental data, only briefly published up to now. The aim of this study is to present the refractive and histopathological data of ISR implants in rabbits and to compare these results with the clinical data actually available.

Methods: Expansion/constriction effects were evaluated with a ring of constant size (7.5 x 0.5 x 0.2 mm) in channels of 7.0, 7.5, or 8.0 mm in diameter, volume effects by implantation of 7.5-mm rings with varying thickness (0.2, 0.3, 0.4 mm) into a channel of 7.5 mm, respectively. Refractive power was measured preoperatively and at day (D) 7, D14, D30 for the first and the second experiment, plus D60, D90 for the second experiment. Histological evaluations of the induced morphological changes were additionally performed at all time intervals.

Results: Significant (P<0.05) flattening of the cornea was obtained in all but the first (constant ring, 7.0-mm channel) implants postoperatively at D7 and/or D14, with mean dioptric changes up to -5.03+/-2.92 compared with controls. However, from D30 on, there was no statistically significant difference between operated and control eyes. Biomicroscopy and histology of the implanted eyes revealed good biocompatibility, with only rare major complications such as stromal abscess or massive neovascularization.

Conclusions: Although our implantation technique differs slightly from that employed in the recent FDA studies, our results tend to confirm the maximal achievable refractive change of about -5 dpt with this procedure. Furthermore, this study is the first to demonstrate that in rabbits, ISR implantation has only a shortterm effect on refractive power. Our results indicate that long-term refractive follow-up may be necessary in human eyes prior to the introduction of ISRs as a routine procedure in refractive surgery.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s004179900083DOI Listing
June 2000

Publication Analysis

Top Keywords

second experiment
8
corneal ring
8
intrastromal corneal
8
implants rabbits
4
size channels
4
constant size
4
ring constant
4
evaluated ring
4
effects evaluated
4
expansion/constriction effects
4
availablemethods expansion/constriction
4
data availablemethods
4
clinical data
4
compare clinical
4
rabbits compare
4
time intervalsresults
4
isr implants
4
diameter volume
4
histopathological data
4
refractive histopathological
4

Keyword Occurance

Similar Publications

Effects of dietary supplementation of chromium methionine chelate on growth performance, oxidative stress, hematological indices, and carcass traits of broiler chickens.

Authors:
Ibrahim M I Youssef Ibrahim M I Abdo Hassan F A Elsukkary Magdy F El-Kady Magdy Elsayed

Trop Anim Health Prod 2022 Aug 16;54(5):267. Epub 2022 Aug 16.

United BioMed Company for Feed Premixes and Chemicals, Cairo, Egypt.

This study was conducted to evaluate the dietary effects of chromium methionine (Cr-Meth) chelate on growth performance, oxidative stress parameters, blood biochemistry, and carcass traits of broiler chickens. An experiment was conducted on 34,000 1-day-old straight-run broiler chicks (Indian River; 42.0 ± 0. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Bacterial Keystone Taxa Regulate Carbon Metabolism in the Earthworm Gut.

Authors:
Guofan Zhu Olaf Schmidt Lu Luan Jingrong Xue Jianbo Fan Stefan Geisen Bo Sun Yuji Jiang

Microbiol Spectr 2022 Aug 16:e0108122. Epub 2022 Aug 16.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciencesgrid.9227.e, Nanjing, China.

As important ecosystem engineers in soils, earthworms strongly influence carbon cycling through their burrowing and feeding activities. Earthworms do not perform these roles in isolation, because their intestines create a special habitat favorable for complex bacterial communities. However, how the ecological functioning of these earthworm-microbe interactions regulates carbon cycling remains largely unknown. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

NORAD Promotes the Viability, Migration, and Phenotypic Switch of Human Vascular Smooth Muscle Cells during Aortic Dissection via LIN28B-Mediated TGF- Promotion and Subsequent Enhanced Glycolysis.

Authors:
Shi-Bo Xia Zhuang-Bo Tian Wenbo Zhang Hao Zhang

Biomed Res Int 2022 6;2022:5333928. Epub 2022 Aug 6.

Department of Vascular Surgery, Changhai Hospital, Second (Navy) Military Medical University, Shanghai 200433, China.

Glucose metabolism reprogramming is an important reason for the functional remodeling, growth, and migration of vascular smooth muscle cells (VSMCs). It is also an important basis for the occurrence and development of aortic dissection (AD), but the specific regulatory factors are not clear. Noncoding RNA activated by DNA damage (NORAD) is dysfunctional in many diseases, but the role of NORAD in AD etiology is unclear. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Testing Behavioral Nudges and Prompts in Digital Courses for the Self-guided Treatment of Depression and Anxiety: Protocol for a 3-Arm Randomized Controlled Trial.

Authors:
Renante Rondina Trevor van Mierlo Rachel Fournier

JMIR Res Protoc 2022 Aug 15;11(8):e37231. Epub 2022 Aug 15.

Evolution Health Systems, Toronto, ON, Canada.

Background: Despite showing strong evidence of positive outcomes, a common problem in the field of digital health is poor engagement and adherence. Non-health care, for-profit digital ventures, such as Facebook, LinkedIn, and Twitter, conduct behavioral experiments to increase user engagement. To our knowledge, digital health organizations have not published similar types of experiments in ad libitum environments, and there are limited published data indicating whether nudges and prompts can be leveraged to increase engagement with digital health interventions. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Light-induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction.

Authors:
Andrzej Żak Olga Kaczmarczyk

J Vis Exp 2022 Jul 26(185). Epub 2022 Jul 26.

Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology.

The current protocol describes the modifications of the transmission electron microscope (TEM) setup for in situ light-induced observations. A glass optical fiber inserted into the electron column above the objective lens polepiece, and a laser, an adjustable light source, was used to fabricate the device. After the illuminator has been calibrated using an external measuring system, it allows one to adjust the intensity of the lighting to the needs of the observed process. Read More

View Article and Full-Text PDF
July 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap