Adv Exp Med Biol 1999 ;455:85-92
Department of Dermatology, Warsaw School of Medicine, Poland.
Rheumatology (Oxford) 2015 Mar 3;54(3):528-35. Epub 2014 Sep 3.
Department of Medical Genetics, University of Oslo and Oslo University Hospital Ullevål, Rheumatology Unit, Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Medical Genetics, University of Oslo and Oslo University Hospital Ullevål, Rheumatology Unit, Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objective: The Norwegian nationwide MCTD cohort was established to obtain unbiased data on key disease issues, and thereby reappraise the concept of MCTD. In the current study, the aims were to obtain detailed HLA profile data on the large Norwegian MCTD cohort and compare these with the HLA profiles of ethnically matched healthy controls and related CTD controls.
Methods: HLA profiles, determined by sequence-based typing of HLA-B* and DRB1*, were compared between four control groups of Norwegian ancestry, SLE (n = 96), SSc (n = 95), PM/DM (n = 84), healthy individuals (n = 282), the complete MCTD cohort (n = 155) and MCTD subsets defined by key clinical parameters. Read More
Curr Opin Rheumatol 1993 Nov;5(6):809-15
Department of Clinical Immunology, University Hospital Groningen, The Netherlands.
Connective tissue diseases (CTDs) frequently present as undifferentiated disorders that may or may not develop into one of the well defined CTDs. The natural evolution of the early undifferentiated CTDs is not well known. Some years ago a cooperative study was started on 410 patients with early CTD; within this group, 48 patients had early scleroderma. Read More
Curr Opin Rheumatol 1999 Nov;11(6):468-74
Centre for Rheumatology, Department of Medicine, University College London, UK.
Myositis-overlap syndromes are characterized by a heterogeneous group of clinical syndromes of which many are closely linked with specific autoantibodies. Clinical and laboratory-based research into this fascinating group of syndromes have given us clues in elucidating the role of immunogenetic, environmental influences on the etiopathogenesis of autoimmune disease. Patients positive for anti-snU1 RNP antibody often present with a constellation of "autoimmune-related" clinical features, often not fulfilling the diagnostic criteria for a single disease entity. Read More
Clin Exp Rheumatol 2003 May-Jun;21(3):313-20
Division of Immunology, 1st Department of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.
Objective: To determine the clinical symptoms and the panel of autoantibodies of patients with early undifferentiated connective tissue disease (UCTD) followed for at least 1 year.
Methods: 716 UCTD patients with manifestations suggestive but not diagnostic of specific connective tissue disease (CTD) were recruited and followed up between 1994-1999. The patients with early UCTD were subdivided into those with isolated Raynaud's phenomenon (RP) (50 patients), unexplained polyarthritis (31 patients) and "true" UCTD (665 patients). Read More